Thesis co-supervised by Dr. K. Ferji (LCPM), Prof. J-L. Six (LCPM) & Prof. M. Lahcini (IMEDLab/Morocco)
"During my PhD, which I defended in 2025, and which was supported by the Eiffel Excellence Scholarship, I explored amphiphilic glycopolymers derived from polysaccharides as next-generation nanocarriers for drug delivery. While PEG-based nanovectors dominate current clinical applications, their limitations have recently raised concerns. My project focused on chitosan derivatives, a bio-based, biodegradable, and positively charged polysaccharide with intrinsic bioactivities relevant to tissue engineering and gene/drug delivery.
"During my PhD, which I defended in 2025, and which was supported by the Eiffel Excellence Scholarship, I explored amphiphilic glycopolymers derived from polysaccharides as next-generation nanocarriers for drug delivery. While PEG-based nanovectors dominate current clinical applications, their limitations have recently raised concerns. My project focused on chitosan derivatives, a bio-based, biodegradable, and positively charged polysaccharide with intrinsic bioactivities relevant to tissue engineering and gene/drug delivery.
By combining chitosan with hydrophobic blocks, I aimed to generate amphiphilic glycopolymers able to self-assemble in water into advanced morphologies (such as vesicles). Unlike traditional solid nanoparticles, these vesicular nanostructures can encapsulate both hydrophilic and hydrophobic compounds simultaneously. In addition, I introduced light-responsive functionalities, enabling external control over drug release. This strategy opens new perspectives for smart nanocarriers in nanomedicine."
Jihad Oumerri, Wan Nurhidayah Wan Hanaffi, Hicham Qayouh, A. Arteni, Mohammed Lahcini, J. Six, K. Ferji*
ACS Applied Polymer Materials, vol. 7(15), 2025, pp. 10318–10325
Erika Paola Fonseca Parra, Jihad Oumerri, A. Arteni, J. Six, S. Armes, K. Ferji*
Macromolecules, vol. 58(1), 2025, pp. 61–73
Niang Saye, Jihad Oumerri, A. Arteni, J. Six, K. Ferji*
Macromolecular rapid communications, 2025, pp. e00412
Jihad Oumerri, Hicham Qayouh, A. Arteni, J. Six, Mohammed Lahcini, K. Ferji*
ChemPhysChem, 2024, pp. e202400291