Journal article
Jihad Oumerri, Hicham Qayouh, A. Arteni, J. Six, Mohammed Lahcini, K. Ferji*
ChemPhysChem, 2024, pp. e202400291
ChemPhysChem, 2024, pp. e202400291
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Oumerri, J., Qayouh, H., Arteni, A., Six, J., Lahcini, M., & Ferji*, K. (2024). One-pot Formulation of Cationic Oligochitosan Coated Nanoparticles via Photo- Polymerization Induced Self-Assembly. ChemPhysChem, e202400291.
Chicago/Turabian
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Oumerri, Jihad, Hicham Qayouh, A. Arteni, J. Six, Mohammed Lahcini, and K. Ferji*. “One-Pot Formulation of Cationic Oligochitosan Coated Nanoparticles via Photo- Polymerization Induced Self-Assembly.” ChemPhysChem (2024): e202400291.
MLA
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Oumerri, Jihad, et al. “One-Pot Formulation of Cationic Oligochitosan Coated Nanoparticles via Photo- Polymerization Induced Self-Assembly.” ChemPhysChem, 2024, p. e202400291.
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@article{jihad2024a,
title = {One-pot Formulation of Cationic Oligochitosan Coated Nanoparticles via Photo- Polymerization Induced Self-Assembly.},
year = {2024},
journal = {ChemPhysChem},
pages = {e202400291},
author = {Oumerri, Jihad and Qayouh, Hicham and Arteni, A. and Six, J. and Lahcini, Mohammed and Ferji*, K.}
}
Abstract
During last few decades, oligochitosan (OCS)-coated nanoparticles have received great interest for nanomedicine, food and environment applications. However, their current formulation techniques are time-consuming with multi-synthesis/purification steps and sometimes require the use of organic solvents, crosslinkers and surfactants. Herein, we report a facile and rapid one-pot synthesis of OCS-based nanoparticles using photo-initiated reversible addition fragmentation chain transfer polymerization-induced self-assembly (Photo-RAFT PISA) under UV-irradiation at room temperature. To achieve this, OCS was first functionalized by a chain transfer agent (CTA) resulting in a macromolecular chain transfer agent (OCS-CTA), which will act as a reactive electrostatic/steric stabilizer. Owing to its UV-sensitivity, OCS-CTA was then used as photo-iniferter to initiate the polymerization of 2-hydroxypropyl methacrylate (HPMA) in aqueous acidic buffer, resulting in OCS-g-PHPMA amphiphilic grafted copolymers which self-assemble into nano-objects. Transmission electron microscopy and light scattering analysis reveal formation of spherical nanostructures.