Thesis co-supervised by Dr. K. Ferji (LCPM) & Prof. J-L. Six (LCPM)
"During my PhD, completed in 2022 (ANR JCJC project), I explored the self-assembly of amphiphilic glycopolymers (AGP) as a sustainable alternative to PEG-based nanocarriers. My goal was to design new glyco-nanostructures (GNS) with advanced morphologies suitable for drug delivery applications.
"During my PhD, completed in 2022 (ANR JCJC project), I explored the self-assembly of amphiphilic glycopolymers (AGP) as a sustainable alternative to PEG-based nanocarriers. My goal was to design new glyco-nanostructures (GNS) with advanced morphologies suitable for drug delivery applications.
To achieve this, I used polymerization-induced self-assembly (PISA), a modern and efficient strategy that enables the direct formation of nanostructures in water at high concentration, without organic solvents. This approach allowed me to generate unprecedented morphologies of AGP-based nanostructures, which had rarely been observed before in this field.
Beyond synthesis, I carried out a detailed physico-chemical characterization of these systems using advanced scattering and imaging techniques, and also explored their cytotoxicity and drug encapsulation properties in collaboration with partners. The originality of this work was recognized by the French Polymer Group (GFP) National PhD Award in 2023."
Progress in Aqueous Dispersion RAFT PISA
D. Ikkene, J. Six, K. Ferji*
European Polymer Journal, 2023, p. 111848
D. Ikkene, A. Arteni, Claire Boulogne, J. Six, K. Ferji*
Macromolecules, vol. 55(11), 2022, pp. 4268–4275
D. Ikkene, A. Arteni, Malika Ouldali, G. Francius, A. Brûlet, J. Six, K. Ferji*
Biomacromolecules, vol. 22(7), 2021, pp. 3128–3137
D. Ikkene, A. Arteni, Malika Ouldali, J. Six, K. Ferji*
Polymer Chemistry, vol. 11, 2020, pp. 4729-4740
D. Ikkene, A. Arteni, Heliang Song, H. Laroui, J. Six, K. Ferji*
Carbohydrate Polymers, 2020, p. 115943