Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment

Journal article

Mohammad A. I. Al-Hatamleh, E. E A R, J. Boer, K. Ferji, J. Six, Xin Chen, E. Elkord, M. Plebanski, Rohimah Mohamud
Cells, 2019

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Al-Hatamleh, M. A. I., R, E. E. A., Boer, J., Ferji, K., Six, J., Chen, X., … Mohamud, R. (2019). Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment. Cells.

Chicago/Turabian Click to copy
Al-Hatamleh, Mohammad A. I., E. E A R, J. Boer, K. Ferji, J. Six, Xin Chen, E. Elkord, M. Plebanski, and Rohimah Mohamud. “Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment.” Cells (2019).

MLA Click to copy
Al-Hatamleh, Mohammad A. I., et al. “Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment.” Cells, 2019.

BibTeX Click to copy

@article{mohammad2019a,
  title = {Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment},
  year = {2019},
  journal = {Cells},
  author = {Al-Hatamleh, Mohammad A. I. and R, E. E A and Boer, J. and Ferji, K. and Six, J. and Chen, Xin and Elkord, E. and Plebanski, M. and Mohamud, Rohimah}
}

Abstract

Tumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, as well as immunosuppressive cells. There is increasingly evidence that TNFR2 expression in cancer microenvironment has significant implications in cancer progression, metastasis and immune evasion. Although nanomedicine has been extensively studied as a carrier of cancer immunotherapeutic agents, no study to date has investigated TNFR2-targeting nanomedicine in cancer treatment. From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. This perspective review discusses a novel therapeutic strategy based on nanomedicine that has the capacity to target TNFR2 along with inhibition of DNA demethylation. This approach may maximize the anti-cancer potential of nanomedicine-based immunotherapy and, consequently, markedly improve the outcomes of the management of patients with malignancy.