Thesis co-supervised by Dr. K. Ferji (LCPM), Prof. J-L. Six (LCPM) & Dr. R. Mohamud (Universiti Sains Malaysia/Malaysia)
"I am currently pursuing my PhD on the use of polymeric soft nano-objects (polymersomes) to explore new therapeutic strategies against colon cancer. Colon cancer remains one of the leading causes of cancer mortality worldwide, and current treatments often face limitations in efficacy and selectivity. In my project, I focus on the role of TNF antagonists, which can modulate inflammation and tumor progression through the TNF–TNFR2 signaling axis.
"I am currently pursuing my PhD on the use of polymeric soft nano-objects (polymersomes) to explore new therapeutic strategies against colon cancer. Colon cancer remains one of the leading causes of cancer mortality worldwide, and current treatments often face limitations in efficacy and selectivity. In my project, I focus on the role of TNF antagonists, which can modulate inflammation and tumor progression through the TNF–TNFR2 signaling axis.
My research aims to investigate how polymersomes — either “naked” or conjugated with TNF antagonists — can influence cancer cell behavior, cytokine secretion, and regulatory T cell responses. By studying these interactions, I hope to clarify the potential of polymersomes as drug delivery vehicles or as adjuvant systems capable of reshaping the tumor microenvironment. This work bridges polymer science and cancer immunology, and may open the way to novel nanomedicine approaches for colon cancer treatment."
Publications from this PhD:
Jihad Oumerri, Wan Nurhidayah Wan Hanaffi, Hicham Qayouh, A. Arteni, Mohammed Lahcini, J. Six, K. Ferji*
ACS Applied Polymer Materials, vol. 7(15), 2025, pp. 10318–10325
Nanoparticles and Gut Microbiota in Colorectal Cancer
Komathi Perumal, Suhana Ahmad, Manali Haniti Mohd-Zahid, Wan Nurhidayah Wan Hanaffi, Iskander Z.A., J. Six, K. Ferji, J. Jaafar, J. Boer, M. Plebanski, V. Uskoković, Rohimah Mohamud
Frontiers in Nanotechnology, 2021